Gemfibrozil

Chemical formula: C₁₅H₂₂O₃  Molecular mass: 250.333 g/mol  PubChem compound: 3463

Therapeutic indications

Gemfibrozil is indicated for:

Severe hypertriglyceridaemia, mixed hyperlipidaemia, primary hypercholesterolaemia

Population group: only adults (18 years old or older)

Gemfibrozil is indicated as an adjunct to diet and other non-pharmacological treatment (e.g. exercise, weight reduction) for the following:

  • Treatment of severe hypertriglyceridaemia with or without low HDL cholesterol.
  • Mixed hyperlipidaemia when a statin is contraindicated or not tolerated.
  • Primary hypercholesterolaemia when a statin is contraindicated or not tolerated.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Gemfibrozil is contraindicated in the following cases:

Hepatic impairment

Hepatic insufficiency

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Gall bladder disease, biliary tract disease

at least one of
Gallbladder disorder
Disease of biliary system

Repaglinide

Repaglinide

Dasabuvir

Dasabuvir

Selexipag

Selexipag

HMG CoA reductase inhibitors

HMG CoA reductase inhibitors

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