Golimumab

Therapeutic indications

Golimumab is indicated for:

Rheumatoid arthritis

Population group: only adults (18 years old or older)

Golimumab, in combination with methotrexate (MTX), is indicated for:

  • the treatment of moderate to severe, active rheumatoid arthritis in adults when the response to disease-modifying anti-rheumatic drug (DMARD) therapy including MTX has been inadequate.
  • the treatment of severe, active and progressive rheumatoid arthritis in adults not previously treated with MTX.

Golimumab, in combination with MTX, has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Psoriatic arthritis

Population group: only adults (18 years old or older)

Golimumab, alone or in combination with MTX, is indicated for the treatment of active and progressive psoriatic arthritis in adult patients when the response to previous DMARD therapy has been inadequate. Golimumab has been shown to reduce the rate of progression of peripheral joint damage as measured by X-ray in patients with polyarticular symmetrical subtypes of the disease and to improve physical function.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Polyarticular juvenile idiopathic arthritis

Population group: only adults (18 years old or older)

Golimumab in combination with MTX is indicated for the treatment of polyarticular juvenile idiopathic arthritis in children 2 years of age and older, who have responded inadequately to previous therapy with MTX.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Axial spondyloarthritis

Population group: only adults (18 years old or older)

Ankylosing spondylitis (AS)

Golimumab is indicated for the treatment of severe, active ankylosing spondylitis in adults who have responded inadequately to conventional therapy.

Non-radiographic axial spondyloarthritis (nr-Axial SpA)

Golimumab is indicated for the treatment of adults with severe, active non-radiographic axial spondyloarthritis with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI) evidence, who have had an inadequate response to, or are intolerant to nonsteroidal anti-inflammatory drugs (NSAIDs).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Ulcerative colitis

Population group: only adults (18 years old or older)

Golimumab is indicated for treatment of moderately to severely active ulcerative colitis in adult patients who have had an inadequate response to conventional therapy including corticosteroids and 6-mercaptopurine (6-MP) or azathioprine (AZA), or who are intolerant to or have medical contraindications for such therapies.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Polyarticular juvenile idiopathic arthritis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Golimumab in combination with MTX is indicated for the treatment of polyarticular juvenile idiopathic arthritis in children 2 years of age and older, who have responded inadequately to previous therapy with MTX.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Golimumab is contraindicated in the following cases:

Moderate or severe heart failure (NYHA class III/IV), congestive heart failure (CHF)

at least one of
Heart failure New York Heart Assosiation Class IΙΙ
Heart failure New York Heart Assosiation Class IV
Congestive heart failure

Tuberculosis

Tuberculosis

Infections, sepsis

at least one of
Infectious disease
Systemic infection

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