Chemical formula: C₈H₈F₃N₃O₄S₂ Molecular mass: 331.292 g/mol PubChem compound: 3647
Hydroflumethiazide is a thiazide diuretic. Diuresis is initiated usually within 2 hours and lasts for about 12-18 hours.
Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastro-intestinal tract.
No pharmacokinetic studies have been performed with hydroflumethiazide in protein binding.
No pharmacokinetic studies have been performed with hydroflumethiazide in biotransformation.
After oral absorption, hydroflumethiazide appears to have a biphasic biological half-life with an estimated alpha-phase of about 2 hours and an estimated beta-phase of about 17 hours; it has a metabolite with a longer half-life, which is extensively bound to the red blood cells. Hydroflumethiazide is excreted in the urine; its metabolite has also been detected in the urine.
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