Hydroxycarbamide Other names: Carbamohydroxamic acid Carbamohydroximic acid Hydroxylurea Hydroxyurea Carbamohydroxyamic acid

Chemical formula: CH₄N₂O₂ Molecular mass: 76.055 g/mol PubChem compound: 3657

Therapeutic indications

Hydroxycarbamide is indicated for:

Vaso-occlusive complications of Sickle Cell Disease

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Hydroxycarbamide indicated for the prevention of vaso-occlusive complications of Sickle Cell Disease in patients over 9 months of age.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

15 mg/kg/day as starting dose and thereafter 20-35 mg/kg/day

Contraindications

Hydroxycarbamide is contraindicated in the following cases:

Severe hepatic impairment

Hepatic failure stage IV

Pregnancy

Lactation

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Toxic ranges of myelosuppression

Myelosuppression

Antiretroviral medicinal products for HIV disease

at least one of

Nucleoside and nucleotide reverse transcriptase inhibitors
Antivirals for treatment of HIV infections, combinations

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