Hydroxycarbamide Other names: Carbamohydroxamic acid Carbamohydroximic acid Hydroxylurea Hydroxyurea Carbamohydroxyamic acid

Chemical formula: CH₄N₂O₂ Molecular mass: 76.055 g/mol PubChem compound: 3657

Therapeutic indications

Hydroxycarbamide is indicated for:

Prevention of vaso-occlusive pain co-occurrent and due to sickle cell disease

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Hydroxycarbamide is indicated for the prevention of recurrent painful vaso-occlusive crises including acute chest syndrome in adults, adolescents and children older than 2 years suffering from symptomatic Sickle Cell Syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

15-35 mg/kg once a day

Contraindications

Hydroxycarbamide is contraindicated in the following cases:

Severe hepatic impairment (Child-Pugh classification C)

Hepatic failure stage IV

Lactation

Severe renal impairment (creatinine clearance <30 ml/min)

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Myelosuppression

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