Iloprost

Chemical formula: C₂₂H₃₂O₄  Molecular mass: 360.494 g/mol  PubChem compound: 5311181

Therapeutic indications

Iloprost is indicated for:

Primary pulmonary hypertension, classified as NYHA functional class III

Population group: only adults (18 years old or older)

Treatment of adult patients with primary pulmonary hypertension, classified as NYHA functional class III, to improve exercise capacity and symptoms.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Severe chronic ischaemia of lower limbs

Population group: only adults (18 - 65 years old)

Treatment of severe chronic ischaemia of lower limbs in patients at risk of amputation, in whom surgical revascularisation or angioplasty has failed or is not indicated, following an interdisciplinary meeting of physicians, surgeons and radiologists.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Severe Raynaud's Phenomenon

Population group: only adults (18 - 65 years old)

Raynaud's phenomenon

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Iloprost is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Severe coronary heart disease

Coronary arteriosclerosis

Unstable angina

Preinfarction syndrome

Myocardial infarction

at least one of
Myocardial infarction
Past history of myocardial infarction

Decompensated cardiac failure

Decompensated cardiac failure

Severe arrhythmias

Arrhythmia

Cerebrovascular events

at least one of
CVA - Cerebrovascular accident
Cerebrovascular disease
CVA - Cerebrovascular accident
H/O: CVA
History of transient ischemic attack

Pulmonary hypertension due to venous occlusive disease

Pulmonary veno-occlusive disease

Valvular defects not related to pulmonary hypertension

Heart valve disorder and additionally not Pulmonary hypertension

Increased the risk of haemorrhage

at least one of
High risk of hemorrhage
Peptic ulcer
Traumatic injury
Intracranial hemorrhage

Pulmonary oedema

Pulmonary edema

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