Iodine

Molecular mass: 253.809 g/mol  PubChem compound: 807

Pharmacodynamic properties

Iodine has a powerful bactericidal action and is used for disinfecting unbroken skin before operations. Iodine is active against fungi, viruses, protozoa, cysts and spores.

Iodine and iodides are used in the pre-operative treatment of hyperthyroidism in conjunction with antithyroid agents. The patient is rendered euthyroid with an antithyroid agent and iodine or iodides are added to the therapy before subtotal thyroidectomy. Iodine aqueous solution is given to render the thyroid firm and avoid the increased vascularity and friability with increased risk of haemorrhage that may result from the use of an antithyroid agent alone.

Pharmacokinetic properties

Iodine is only slightly absorbed when applied to the skin.

Iodine is converted to iodide, which is trapped in the thyroid gland. Iodides are excreted mainly in the urine with smaller amounts excreted in the faeces, sweat and saliva. They cross the placenta and are excreted in breast milk.

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