Chemical formula: C₁₈H₂₄I₃N₃O₉ Molecular mass: 807.115 g/mol PubChem compound: 3741
Ioversol is a non-ionic X-ray contrast medium. Intravascular injection of ioversol opacifies those vessels in the path of the flow of the contrast medium, permitting radiographic visualisation of the internal structures until significant haemodilution occurs.
The pharmacokinetic profile of ioversol, together with its hydrophilic properties and a very low level of binding to serum and plasma proteins, indicate that ioversol is distributed within the extracellular fluid space and eliminated quickly through the kidneys by glomerular filtration. The mean (±se) half-lives after doses of 50 ml and 150 ml were 113 ± 8.4 and 104 ± 15 minutes respectively. Elimination via the faeces is negligible. No significant metabolism, deiodination, or biotransformation of ioversol has been observed.
There were no findings in the preclinical testing of ioversol which could be of relevance for the prescriber in recognising the safety of this product used for the authorised indications.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
