Chemical formula: C₂₅H₂₈N₆O Molecular mass: 428.529 g/mol PubChem compound: 3749
Irbesartan is a potent, orally active, selective angiotensin-II receptor (type AT1) antagonist. It is expected to block all actions of angiotensin-II mediated by the AT1 receptor, regardless of the source or route of synthesis of angiotensin-II. The selective antagonism of the angiotensin-II (AT1) receptors results in increases in plasma renin levels and angiotensin-II levels, and a decrease in plasma aldosterone concentration.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09CA04 | Irbesartan | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09C Angiotensin II antagonists, plain → C09CA Angiotensin II antagonists, plain |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| APROVEL Tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| AVAPRO Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Irbesartan is an active ingredient of these brands:
Albania (AL)
Australia (AU)
Austria (AT)
Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)
Estonia (EE)France (FR)
Germany (DE)Hong Kong (HK)
Ireland (IE)Italy (IT)Lithuania (LT)Malta (MT)
Nigeria (NG)
Poland (PL)Romania (RO)Singapore (SG)
South Africa (ZA)
Spain (ES)Tunisia (TN)
Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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