Isavuconazole

Chemical formula: C₂₂H₁₇F₂N₅OS Molecular mass: 437.47 g/mol

Therapeutic indications

Isavuconazole is indicated for:

Invasive aspergillosis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Isavuconazole is indicated in adults and in paediatric patients from 6 years of age for the treatment of invasive aspergillosis.

Consideration should be given to official guidance on the appropriate use of antifungal agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

200 mg everey 8 h for the first 48 hours and thereafter 200 mg once daily

200 mg every 8 h on Days 1 and 2 and thereafter 200 mg once daily

80-200 mg every 8 h on Days 1 and 2 and thereafter 80-200 mg once daily, based on body weight

For patients weighting ≥37 kg 200 mg every 8 h for the first 48 h and thereafter 200 mg once daily and for patients weighting <37 kg 5.4 mg/kg every 8 h for the first 48 h and thereafter 5.4 mg/kg once daily

Mucormycosis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Isavuconazole is indicated in adults and in paediatric patients from 6 years of age for the treatment of mucormycosis in patients for whom amphotericin B is inappropriate.

Consideration should be given to official guidance on the appropriate use of antifungal agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

200 mg everey 8 h for the first 48 hours and thereafter 200 mg once daily

200 mg every 8 h on Days 1 and 2 and thereafter 200 mg once daily

80-200 mg every 8 h on Days 1 and 2 and thereafter 80-200 mg once daily, based on body weight

For patients weighting ≥37 kg 200 mg every 8 h for the first 48 h and thereafter 200 mg once daily and for patients weighting <37 kg 5.4 mg/kg every 8 h for the first 48 h and thereafter 5.4 mg/kg once daily

Contraindications

Isavuconazole is contraindicated in the following cases:

Ketoconazole

Lactation

Ritonavir

Moderate or strong CYP3A4/5 inducers

at least one of

CYP3A4 inducers
Cytochrome P-450 CYP3A5 moderate inducers
Cytochrome P-450 CYP3A5 strong inducers

Familial short QT syndrome

Short QT syndrome

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Isavuconazole

Therapeutic indications

Invasive aspergillosis

200 mg everey 8 h for the first 48 hours and thereafter 200 mg once daily

200 mg every 8 h on Days 1 and 2 and thereafter 200 mg once daily

80-200 mg every 8 h on Days 1 and 2 and thereafter 80-200 mg once daily, based on body weight

For patients weighting ≥37 kg 200 mg every 8 h for the first 48 h and thereafter 200 mg once daily and for patients weighting <37 kg 5.4 mg/kg every 8 h for the first 48 h and thereafter 5.4 mg/kg once daily

Mucormycosis

200 mg everey 8 h for the first 48 hours and thereafter 200 mg once daily

200 mg every 8 h on Days 1 and 2 and thereafter 200 mg once daily

80-200 mg every 8 h on Days 1 and 2 and thereafter 80-200 mg once daily, based on body weight

For patients weighting ≥37 kg 200 mg every 8 h for the first 48 h and thereafter 200 mg once daily and for patients weighting <37 kg 5.4 mg/kg every 8 h for the first 48 h and thereafter 5.4 mg/kg once daily

Contraindications

Ketoconazole

Lactation

Ritonavir

Moderate or strong CYP3A4/5 inducers

Familial short QT syndrome

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