Ivosidenib

Chemical formula: C₂₈H₂₂ClF₃N₆O₃  Molecular mass: 582.97 g/mol 

Therapeutic indications

Ivosidenib is indicated for:

Acute myeloid leukaemia with an isocitrate dehydrogenase-1 R132 mutation

Population group: only adults (18 years old or older)

Tibsovo in combination with azacitidine is indicated for the treatment of adult patients with newly diagnosed acute myeloid leukaemia (AML) with an isocitrate dehydrogenase-1 (IDH1) R132 mutation who are not eligible to receive standard induction chemotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Locally advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 R132 mutation

Population group: only adults (18 years old or older)

Tibsovo monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic cholangiocarcinoma with an IDH1 R132 mutation who were previously treated by at least one prior line of systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Ivosidenib is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Congenital long QT syndrome

Congenital long QT syndrome

Familial history of sudden death or polymorphic ventricular arrhythmia

at least one of
Family history of sudden death
Ventricular tachycardia, polymorphic

QT/QTc interval >500 msec

Prolonged QT interval

Strong CYP3A4 inducers

Strong potency CYP3A4 inducers

Dabigatran

Dabigatran

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