Ketoconazole

Chemical formula: C₂₆H₂₈Cl₂N₄O₄  Molecular mass: 531.431 g/mol  PubChem compound: 3823

Therapeutic indications

Ketoconazole is indicated for:

Tinea cruris (Jock itch)

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Tinea cruris

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Dandruff

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Pityriasis capitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Seborrheic dermatitis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Seborrheic dermatitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Tinea pedis (athlete's foot)

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Tinea pedis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Tinea versicolor

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Pityriasis versicolor

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Endogenous Cushing's syndrome

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Ketoconazole is indicated for the treatment of endogenous Cushing’s syndrome in adults and adolescents above the age of 12 years.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of dandruff

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Preventive procedure and additionally Pityriasis capitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of seborrheic dermatitis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Preventive procedure and additionally Seborrheic dermatitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Ketoconazole is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Hepatic impairment

Hepatic insufficiency

Methadone

Methadone

Disopyramide, quinidine, dronedarone

at least one of
Disopyramide
Quinidine
Dronedarone

Dabigatran

Dabigatran

Ergot alkaloids

at least one of
Ergot alkaloids
Ergot alkaloids
Ergot alkaloids

Irinotecan

Irinotecan

Telithromycin, clarithromycin in severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)
and additionally at least one of
Telithromycin
Clarithromycin

Triazolam, alprazolam, midazolam

at least one of
Triazolam
Alprazolam
Midazolam

Lurasidone

Lurasidone

Pimozide

Pimozide

Sertindole

Sertindole

Quetiapine

Quetiapine

Saquinavir

Saquinavir

Paritaprevir, ombitasvir

at least one of
Paritaprevir
Ombitasvir

Felodipine, nisoldipine

at least one of
Felodipine
Nisoldipine

Ranolazine

Ranolazine

Eplerenone

Eplerenone

Everolimus, sirolimus

at least one of
Everolimus
Sirolimus

Lovastatin, simvastatin, atorvastatin

at least one of
Lovastatin
Simvastatin
Atorvastatin

Sildenafil, tadalafil, vardenafil

at least one of
Sildenafil
Tadalafil
Vardenafil

Tolvaptan

Tolvaptan

Mizolastine, halofantrine

at least one of
Mizolastine
Halofantrine

CYP3A4-metabolised, P-gp substrates known to prolong the QT interval

at least one of
CYP3A4 substrates
P-glycoprotein substrates
and additionally Drugs prolonging QT interval

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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