Lefamulin

Chemical formula: C₂₈H₄₅NO₅S  Molecular mass: 507.73 g/mol  PubChem compound: 25185057

Therapeutic indications

Lefamulin is indicated for:

Community-acquired pneumonia (CAP)

Population group: only adults (18 years old or older)

Lefamulin is indicated for the treatment of community-acquired pneumonia (CAP) in adults when it is considered inappropriate to use antibacterial agents that are commonly recommended for the initial treatment of CAP or when these have failed.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Lefamulin is contraindicated in the following cases:

Lactation

Lactation

Moderate and strong CYP3A/P-gp inducers

at least one of
Strong potency CYP3A4 inducers
Cytochrome P-450 CYP3A5 strong inducers
Cytochrome P-450 CYP3A5 moderate inducers
Moderate potency CYP3A4 inducers

Strong CYP3A/P-gp inhibitors

at least one of
Strong CYP3A4 inhibitors
Cytochrome P-450 CYP3A5 strong inhibitors
P-glycoprotein inhibitors

Drugs prolonging QT interval

Drugs prolonging QT interval

Known QT prolongation

at least one of
Prolonged QT interval
Long QT syndrome

Electrolyte disturbances, particularly uncorrected hypokalemia

Disorder of electrolytes

Clinically relevant bradycardia, unstable congestive heart failure, history of symptomatic ventricular arrhythmias

at least one of
Bradycardia
Congestive heart failure
Ventricular arrhythmia

Sensitive CYP2C8 substrates

CYP2C8 substrates

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