Leuprorelin Other names: Leuprorelin acetate

Chemical formula: C₅₉H₈₄N₁₆O₁₂  Molecular mass: 1,209.398 g/mol 

Therapeutic indications

Leuprorelin is indicated for:

Prostate cancer

Population group: men, only adults (18 years old or older)

  • Metastatic prostate cancer.
  • Locally advanced prostate cancer, as an alternative to surgical castration.
  • As an adjuvant treatment to radiotherapy in patients with high-risk localised or locally advanced prostate cancer.
  • As an adjuvant treatment to radical prostatectomy in patients with locally advanced prostate cancer at high risk of disease progression.
  • As neo-adjuvant treatment prior to radiotherapy in patients with high-risk localised or locally advanced prostate cancer.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Central precocious puberty

Population group: only children (1 year - 12 years old)

Treatment of central precocious puberty (girls under 9 years of age, boys under 10 years of age).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Endometriosis

Population group: women, only adolescents (12 years - 18 years old) , adults (18 years old or older)

Management of endometriosis, including pain relief and reduction of endometriotic lesions.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Breast cancer

Population group: only adults (18 years old or older)

As treatment in pre- and perimenopausal women with advanced breast cancer suitable for hormonal manipulation.

As adjuvant treatment in combination with tamoxifen or an aromatase inhibitor, of endocrine responsive early stage breast cancer in pre- and perimenopausal women at higher risk of disease recurrence (young age, high grade tumour, lymph node involvement). In women who have received chemotherapy, premenopausal status must be confirmed after completion of chemotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Leuprorelin is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Previous orchiectomy

H/O orchidectomy

Spinal cord compression

Spinal cord compression

Spinal metastases

Secondary malignant neoplasm of vertebral column

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