Liothyronine Other names: Thyroid hormone Triiodothyronine sodium

Chemical formula: C₁₅H₁₁I₃NaNO₄  Molecular mass: 650.974 g/mol  PubChem compound: 5920

Pharmacodynamic properties

Liothyronine sodium is a naturally occurring thyroid hormone.

The biological action of liothyronine sodium is quantitatively similar to that of levothyroxine sodium, but the effects develop in a few hours and disappear within 24 to 48 hours of stopping treatment.

Pharmacokinetic properties

Absorption

Liothyronine sodium is almost completely absorbed from the gastro-intestinal tract.

Distribution

It is less readily bound to plasma proteins than thyroxine. About 0.5% is in the unbound form.

Elimination

The half-life of liothyronine in euthroidism is 1 to 2 days. Thyroid hormones do not readily cross the placenta. Minimal amounts are excreted in breast milk.

Preclinical safety data

No additional data.

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