Lofepramine

Chemical formula: C₂₆H₂₇ClN₂O  Molecular mass: 418.97 g/mol 

Active ingredient description

Lofepramine is a tricyclic antidepressant. It exerts its therapeutic effect by blocking the uptake of noradrenaline by the nerve cell thus increasing the amine in the synaptic cleft and hence the effect on the receptors.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N06AA07 Lofepramine N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AA Non-selective monoamine reuptake inhibitors
Discover more medicines within N06AA07

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 23047-25-8
DrugBank Drug: DB13411
RxNorm Ingredient: 6465
SNOMED-CT Concept: 395772004
Lofepramine (substance)
UNII Identifier: OCA4JT7PAW
LOFEPRAMINE

Medicines

Lofepramine is an active ingredient of these brands:

Ireland (IE)

  • GAMANIL as LOFEPRAMINE HYDROCHLORIDE

Japan (JP)

  • AMPLIT as LOFEPRAMINE HYDROCHLORIDE

South Africa (ZA)

  • EMDALEN as LOFEPRAMINE HYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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