Chemical formula: C₁₁H₁₂Cl₂N₂O Molecular mass: 259.132 g/mol PubChem compound: 30668
Lofexidine is a central alpha-2 adrenergic agonist that binds to receptors on adrenergic neurons. This reduces the release of norepinephrine and decreases sympathetic tone. It is used for mitigation of opioid withdrawal symptoms to facilitate abrupt opioid discontinuation in adults.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N07BC04 | Lofexidine | N Nervous system → N07 Other nervous system drugs → N07B Drugs used in addictive disorders → N07BC Drugs used in opioid dependence |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| LUCEMYRA Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Lofexidine is an active ingredient of these brands:
United States (US)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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