Lomitapide

Chemical formula: C₃₉H₃₇F₆N₃O₂  Molecular mass: 693.72 g/mol  PubChem compound: 9853053

Therapeutic indications

Lomitapide is indicated for:

Homozygous familial hypercholesterolaemia (HoFH)

Population group: only adults (18 years old or older)

Lomitapide is indicated as an adjunct to a low-fat diet and other lipid-lowering medicinal products with or without low density lipoprotein (LDL) apheresis in adult patients with homozygous familial hypercholesterolaemia (HoFH).

Genetic confirmation of HoFH should be obtained whenever possible. Other forms of primary hyperlipoproteinemia and secondary causes of hypercholesterolaemia (e.g., nephrotic syndrome, hypothyroidism) must be excluded.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Lomitapide is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Moderate or severe hepatic impairment, persistent abnormal liver function tests

at least one of
Hepatic failure stage III
Hepatic failure stage IV
Abnormal liver function
Liver function tests abnormal

Bowel disease

at least one of
Inflammatory bowel disease
Intestinal malabsorption

Concomitant administration of >40 mg simvastatin

Simvastatin

Strong or moderate CYP3A4 inhibitors

at least one of
Strong CYP3A4 inhibitors
Moderate CYP3A4 inhibitors

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