Loperamide

Chemical formula: C₂₉H₃₃ClN₂O₂ Molecular mass: 477.038 g/mol PubChem compound: 3955

Therapeutic indications

Loperamide is indicated for:

Acute diarrhoea

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For the symptomatic treatment of acute diarrhoea in adults and children aged 12 years and over.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Diarrhoea associated with irritable bowel syndrome

Population group: only adults (18 years old or older)

For the symptomatic treatment of acute episodes of diarrhoea associated with Irritable Bowel Syndrome in adults aged 18 years and over following initial diagnosis by a doctor.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Loperamide is contraindicated in the following cases:

Acute dysentery

Dysenteric diarrhea

Acute ulcerative colitis

Bacterial enterocolitis caused by invasive organisms including Salmonella, Shigella and Campylobacter

at least one of

Colitis caused by Salmonella
Shigellosis
Enteric campylobacteriosis

Pseudomembranous colitis associated with the use of broad-spectrum antibiotics

Antibiotic enterocolitis

Ileus, megacolon, toxic megacolon, constipation, abdominal distension

at least one of

Ileus
Dilatation of colon
† Toxic megacolon
Constipation
Abdominal distension symptom

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