Lorazepam

Chemical formula: C₁₅H₁₀Cl₂N₂O₂ Molecular mass: 321.158 g/mol PubChem compound: 3958

Therapeutic indications

Lorazepam is indicated for:

Severe anxiety

Population group: only adults (18 - 65 years old)

Symptomatic relief of anxiety that is severe, disabling or subjecting the individual to unacceptable distress occurring alone or in association with insomnia or short-term psychometric, organic or psychotic illness.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1-4 mg in 2 divided doses daily

0.025-0.100 mg/kg in 1-4 divided doses daily

0.025-0.100 mg/kg in 1-4 divided doses daily

Severe anxiety

Population group: only elderly (65 years old or older)

Symptomatic relief of anxiety that is severe, disabling or subjecting the individual to unacceptable distress occurring alone or in association with insomnia or short-term psychometric, organic or psychotic illness.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1-2 mg in 2 divided doses daily

Premedication

Population group: only adults (18 - 65 years old)

Before operative dentistry and general surgery.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2-4 mg once 1-2 hours before the procedure or the night before operation

0.05 mg/kg once

0.05 mg/kg once

Premedication

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Before operative dentistry and general surgery.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.05 mg/kg once 1-2 hours before the procedure or the night before operation

Premedication

Population group: only elderly (65 years old or older)

Before operative dentistry and general surgery.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2-4 mg once 1-2 hours before the procedure or the night before operation

Status epilepticus

Population group: only adults (18 - 65 years old)

Status epilepticus

For this indication, competent medicine agencies globally authorize below treatments (click for details):

4mg once

Status epilepticus

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Status epilepticus

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2mg once

Status epilepticus

Population group: only elderly (65 years old or older)

Status epilepticus

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2mg once

Contraindications

Lorazepam is contraindicated in the following cases:

Pregnancy

Pregnancy

Myasthenia gravis

Myasthenia gravis

Severe hepatic insufficiency

Hepatic failure stage IV

Acute pulmonary insufficiency, respiratory depression, sleep apnoea

at least one of

Respiratory insufficiency
Decreased respiratory function
Sleep apnea

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