High molecular weight (4000) macrogols are long linear polymers which retain water molecules by means of hydrogen bonds. When administered by the oral route, they lead to an increase in volume of intestinal fluids.
The volume of unabsorbed intestinal fluid accounts for the laxative properties of the solution.
The pharmacokinetic data confirm that macrogol undergoes neither gastrointestinal resorption nor biotransformation following oral ingestion.
Toxicological studies conducted in different animal species did not reveal any sign of systemic or local gastrointestinal toxicity. Macrogol had no teratogenic or mutagenic effect.
No carcinogenicity studies have been performed.
Macrogol was not teratogenic in rats or rabbits.
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