Maprotiline Other names: Maprotiline hydrochloride

Chemical formula: C₂₀H₂₃N  Molecular mass: 277.403 g/mol  PubChem compound: 4011

Therapeutic indications

Maprotiline is indicated for:

Depression

Population group: only adults (18 years old or older)

  • Depression
  • Endogenous and late-onset (involutional) depression.
  • Psychogenic, reactive, and neurotic depression, exhaustion depression.
  • Somatogenic depression.
  • Masked depression.
  • Menopausal depression.
  • Other depressive mood disorders characterised by anxiety, dysphoria, or irritability; apathetic states (especially in the elderly); psychosomatic and somatic symptoms with underlying depression and/or anxiety.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Maprotiline is contraindicated in the following cases:

Effects on ability to drive and use machines

Effects on ability to drive and use machines

Pregnancy

Pregnancy

Lactation

Lactation

Convulsive disorder, a lowered convulsion threshold

Seizure disorder

Acute stage of myocardial infarction, cardiac conduction defects

at least one of
Acute myocardial infarction
Recent myocardial infarction
Conduction disorder of the heart
Congenital long QT syndrome

Severe hepatic impairment

Hepatic failure stage IV

Severe renal impairment, hepatic porphyria

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)
Hepatic porphyria

Narrow-angle glaucoma

Angle-closure glaucoma

Urinary retention

Retention of urine

Monoamine oxidase (MAO) inhibitors

Monoamine oxidase inhibitors (MAOIs)

Acute poisoning with alcohol, hypnotics, or psychotropic agents

at least one of
Toxic effect of ethyl alcohol
Poisoning by hypnotic agent
Poisoning by psychotropic agent
Poisoning by analgesic drug

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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