Methadone

Chemical formula: C₂₁H₂₇NO  Molecular mass: 309.445 g/mol  PubChem compound: 4095

Active ingredient description

Methadone is a synthetic opioid analgesic similar to morphine although less sedative. It acts on the CNS system and smooth muscles via the peripheral nervous system.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N07BC02 Methadone N Nervous system → N07 Other nervous system drugs → N07B Drugs used in addictive disorders → N07BC Drugs used in opioid dependence
Discover more medicines within N07BC02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
PHYSEPTONE MIXTURE Oral solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
PHYSEPTONE Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
METHADOSE Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 76-99-3
DrugBank Drug: DB00333
KEGG Drug: D08195
PubChem Compound: 4095
RxNorm Ingredient: 6813
SNOMED-CT Concept: 387286002
Methadone (substance)
UNII Identifier: UC6VBE7V1Z
METHADONE

Medicines

Methadone is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

  • METHASAN as METHADONE HYDROCHLORIDE
  • MISYO as METHADONE HYDROCHLORIDE

Brazil (BR)

  • MYTEDOM as METHADONE HYDROCHLORIDE

Canada (CA)

Croatia (HR)

Ecuador (EC)

Finland (FI)

  • DOLMED as METHADONE HYDROCHLORIDE

France (FR)

  • ZORYON as METHADONE HYDROCHLORIDE

Ireland (IE)

Japan (JP)

Mexico (MX)

  • AMIDONE as METHADONE HYDROCHLORIDE

New Zealand (NZ)

Poland (PL)

  • MISYO as METHADONE HYDROCHLORIDE
  • SUBLANA as METHADONE HYDROCHLORIDE

Romania (RO)

South Africa (ZA)

  • MISYO as METHADONE HYDROCHLORIDE

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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