Metoclopramide

Chemical formula: C₁₄H₂₂ClN₃O₂  Molecular mass: 299.796 g/mol  PubChem compound: 4168

Therapeutic indications

Metoclopramide is indicated for:

Prevention and treatment of post-operative nausea and vomiting (PONV)

Population group: only adults (18 years old or older)

at least one of
Postoperative nausea and vomiting
Preventive procedure and additionally Postoperative nausea and vomiting

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prevention and treatment of radiotherapy induced nausea and vomiting (RINV)

Population group: only adults (18 years old or older)

at least one of
Radiation-induced nausea and vomiting
Preventive procedure and additionally Radiation-induced nausea and vomiting

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Symptomatic treatment of nausea and vomiting

Population group: only adults (18 years old or older)

Nausea and vomiting

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Duodenal intubation

Population group: only adults (18 years old or older)

Insertion of tube into duodenum

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Radiographic imaging procedure

Population group: only adults (18 years old or older)

Radiographic imaging procedure

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prevention of delayed chemotherapy induced nausea and vomiting (CINV)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

at least one of
Chemotherapy-induced nausea and vomiting
Preventive procedure and additionally Chemotherapy-induced nausea and vomiting

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Metoclopramide is contraindicated in the following cases:

Gastrointestinal haemorrhage

Gastrointestinal hemorrhage

Gastrointestinal mechanical obstruction

Gastrointestinal obstruction

Gastrointestinal perforation

Gastrointestinal perforation

Pheochromocytoma

Phaeochromocytoma

Neuroleptic or metoclopramide-induced tardive dyskinesia

Neuroleptic-induced tardive dyskinesia

Epilepsy

Epilepsy

Levodopa

Levodopa

Parkinson's disease

Parkinson's disease

Dopaminergic agonists

Dopamine agonists

NADH cytochrome-b5 deficiency

Congenital methemoglobinemia due to NADH-cytochrome b5 reductase 3 deficiency

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