Chemical formula: C₂₂H₂₈N₄O₆ Molecular mass: 444.481 g/mol PubChem compound: 4212
Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01DB07 | Mitoxantrone | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01D Cytotoxic antibiotics and related substances → L01DB Anthracyclines and related substances |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| MITOXANTRONE Concentrate for solution for infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Mitoxantrone is an active ingredient of these brands:
Australia (AU)Austria (AT)
Brazil (BR)
Ecuador (EC)Estonia (EE)France (FR)
Hong Kong (HK)
Japan (JP)
Lithuania (LT)Malta (MT)New Zealand (NZ)Romania (RO)Spain (ES)
Tunisia (TN)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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