Chemical formula: C₃₅H₃₆ClNO₃S Molecular mass: 586.183 g/mol PubChem compound: 5281040
Montelukast is an orally active compound which binds with high affinity and selectivity to the CysLT1 receptor. Τhe CysLT type-1 (CysLT1) receptor is found in the human airway (including airway smooth muscle cells and airway macrophages) and on other pro-inflammatory cells (including eosinophils and certain myeloid stem cells). CysLTs have been correlated with the pathophysiology of asthma and allergic rhinitis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R03DC03 | Montelukast | R Respiratory system → R03 Drugs for obstructive airway diseases → R03D Other systemic drugs for obstructive airway diseases → R03DC Leukotriene receptor antagonists |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SINGULAIR Tablet / Chewable Tablet / Granule | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| MONTELUKAST Film-coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Montelukast is an active ingredient of these brands:
United States (US)
Austria (AT)Brazil (BR)
Canada (CA)
Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Israel (IL)
Italy (IT)
Malta (MT)Mexico (MX)
Netherlands (NL)
Nigeria (NG)Poland (PL)Singapore (SG)South Africa (ZA)
Spain (ES)Tunisia (TN)Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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