Chemical formula: C₃₃H₄₇NO₁₃ Molecular mass: 665.733 g/mol PubChem compound: 5284447
Natamycin is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. The mechanism of action appears to be through binding of the molecule to the sterol moiety of the fungal cell membrane.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A01AB10 | Natamycin | A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment |
| A07AA03 | Natamycin | A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07A Intestinal antiinfectives → A07AA Antibiotics |
| D01AA02 | Natamycin | D Dermatologicals → D01 Antifungals for dermatological use → D01A Antifungals for topical use → D01AA Antibiotics |
| G01AA02 | Natamycin | G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AA Antibiotics |
| S01AA10 | Natamycin | S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AA Antibiotics |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| NATACYN Ophthalmic suspension, drops | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Natamycin is an active ingredient of these brands:
United States (US)Finland (FI)
Hong Kong (HK)New Zealand (NZ)
Poland (PL)
Singapore (SG)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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