Chemical formula: C₁₇H₁₈N₂O₆ Molecular mass: 346.335 g/mol PubChem compound: 4485
Nifedipine is a calcium antagonist of the 1,4-dihydropyridine type. Calcium antagonists reduce the transmembranal influx of calcium ions through the slow calcium channel into the cell. As a specific and potent calcium antagonist, nifedipine acts particularly on the cells of the myocardium and the smooth muscle cells of the coronary arteries and the peripheral resistance vessels. The main action of nifedipine is to relax arterial smooth muscle, both in the coronary and peripheral circulation. Nifedipine Tablets are formulated to achieve controlled delivery of nifedipine in a release profile sufficient to enable once-daily administration to be effective in clinical use.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C08CA05 | Nifedipine | C Cardiovascular system → C08 Calcium channel blockers → C08C Selective calcium channel blockers with mainly vascular effects → C08CA Dihydropyridine derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PROCARDIA XL Extended release tablet | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| NIDEF Prolonged release tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| PROCARDIA Capsule | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Nifedipine is an active ingredient of these brands:
United States (US)Brazil (BR)Canada (CA)Croatia (HR)Ecuador (EC)
France (FR)Israel (IL)
Lithuania (LT)Netherlands (NL)Nigeria (NG)Romania (RO)Singapore (SG)South Africa (ZA)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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