Nirmatrelvir and Ritonavir

Therapeutic indications

Nirmatrelvir and Ritonavir is indicated for:

Coronavirus disease 2019 (COVID-19)

Population group: only adults (18 - 65 years old)

Nirmatrelvir in combination with ritonavir is indicated for the treatment of coronavirus disease 2019 (COVID-19) in adults who do not require supplemental oxygen and who are at increased risk for progressing to severe COVID-19.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Nirmatrelvir and Ritonavir is contraindicated in the following cases:

Strong CYP3A inducers

at least one of
Strong potency CYP3A4 inducers
Cytochrome P-450 CYP3A5 strong inducers

Alfuzosin

Alfuzosin

Pethidine, piroxicam, propoxyphene

at least one of
Pethidine
Piroxicam
Dextropropoxyphene

Ranolazine

Ranolazine

Neratinib, venetoclax

at least one of
Neratinib
Venetoclax

Amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, quinidine

at least one of
Amiodarone
Bepridil
Dronedarone
Encainide
Flecainide
Propafenone
Quinidine

Fusidic acid, rifampicin

at least one of
Fusidic acid
Rifampicin

Carbamazepine, phenobarbital, phenytoin

at least one of
Carbamazepine
Phenobarbital
Phenytoin

Colchicine

Colchicine

Astemizole, terfenadine

at least one of
Astemizole
Terfenadine

Lurasidone, pimozide, clozapine, quetiapine

at least one of
Lurasidone
Pimozide
Clozapine
Quetiapine

Dihydroergotamine, ergonovine, ergotamine, methylergonovine

at least one of
Dihydroergotamine
Ergometrine
Ergotamine
Methergine

Cisapride

Cisapride

St. John's wort (Hypericum perforatum)

Hypericum perforatum (St John's Wort)

Lovastatin, simvastatin, lomitapide

at least one of
Lovastatin
Simvastatin
Lomitapide

Avanafil, sildenafil, vardenafil

at least one of
Avanafil
Sildenafil
Vardenafil

Clorazepate, diazepam, estazolam, flurazepam, midazolam, triazolam

at least one of
Clorazepate
Diazepam
Estazolam
Flurazepam
Midazolam
Triazolam

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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