Ofloxacin

Chemical formula: C₁₈H₂₀FN₃O₄  Molecular mass: 361.368 g/mol  PubChem compound: 4583

Active ingredient description

Ofloxacin is a quinolone-carboxylic acid derivative with a wide range of antibacterial activity against both Gram-negative and Gram-positive organisms. The primary mode of action of the quinolones is the specific inhibition of bacterial DNA gyrase. This enzyme is required for DNA replication, transcription, repair and recombination.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
J01MA01 Ofloxacin J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01M Quinolone antibacterials → J01MA Fluoroquinolones
Discover more medicines within J01MA01
S01AE01 S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AE Fluoroquinolones
Discover more medicines within S01AE01
S02AA16 S Sensory organs → S02 Otologicals → S02A Antiinfectives → S02AA Antiinfectives
Discover more medicines within S02AA16

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
OFLOXACIN Film-coated tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
EXOCIN Eye drops, solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
OCUFLOX Ophthalmic solution FDA, National Drug Code (US) MPI, US: SPL/Old
TARIVID Solution for infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 82419-36-1
CAS Substance: 83380-47-6
DrugBank Drug: DB01165
KEGG Drug: D00453
PubChem Compound: 4583
RxNorm Ingredient: 7623
SNOMED-CT Concept: 387551000
Ofloxacin (substance)
UNII Identifier: A4P49JAZ9H
OFLOXACIN

Medicines

Ofloxacin is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Estonia (EE)

Finland (FI)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

Nigeria (NG)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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