Oxycodone and Naloxone

Therapeutic indications

Oxycodone and Naloxone is indicated for:

Severe pain, which can be adequately managed only with opioid analgesics

Population group: only adults (18 years old or older)

The opioid antagonist naloxone is added to counteract opioid-induced constipation by blocking the action of oxycodone at opioid receptors locally in the gut.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

10 mg of oxycodone and 5 mg of naloxone once every 12 hours

Restless legs syndrome

Population group: only adults (18 years old or older)

Second line symptomatic treatment of patients with severe to very severe idiopathic restless legs syndrome after failure of dopaminergic therapy.

The opioid antagonist naloxone is added to counteract opioid-induced constipation by blocking the action of oxycodone at opioid receptors locally in the gut.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 mg of oxycodone and 2.5 mg of naloxone once every 12 hours

Contraindications

Oxycodone and Naloxone is contraindicated in the following cases:

Moderate hepatic impairment, severe hepatic impairment

at least one of

Hepatic failure stage III
Hepatic failure stage IV

History of opioid abuse

Opioid abuse

Lactation

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