Chemical formula: C₁₆H₂₄N₂O Molecular mass: 260.375 g/mol PubChem compound: 4636
Oxymetazoline hydrochloride is a sympathomimetic amine having vasoconstrictor properties which are utilised in the relief of nasal congestion.
Oximetazoline is an imidazoline derivative. It exhibits sympathomimetic activity and specifically stimulates the α-adrenergic receptors of the sympathetic system. When administered topically to the nose it causes vasoconstriction of the expansed arterioles of the mucosal nose and a concurrent reduction in blood flow. The onset of action takes place within a few minutes and lasts for 6-8 hours.
It also reduces the hypersecretion of the nasal mucosa, ultimately contributing to the decongestion of the nasal mucosa.
Oxymetazoline enters tissues rapidly and local vasoconstriction is normally achieved within 5-10 minutes of intranasal administration. The full effect lasts for 5-6 hours and then gradually subsides over the next 6 hours. Plasma half-life is 5-8 days with 30% of any absorbed drug being excreted in the urine unchanged and 10% being excreted in the faeces.
There are no preclinical data of relevance to the prescriber which are additional to that already included.
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