Oxytocin Other names: Alpha-hypophamine α–hypophamine

Chemical formula: C₄₃H₆₆N₁₂O₁₂S₂ Molecular mass: 1,006.436 g/mol

Therapeutic indications

Oxytocin is indicated for:

Postpartum uterine haemorrhage

Population group: women, only adults (18 - 65 years old)

Postpartum hemorrhage co-occurrent and due to uterine rupture following obstructed labor

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 IU once

Induction of labour

Population group: women, only adults (18 - 65 years old)

Induction of labour for medical reasons; e.g. in cases of post-term gestation, premature rupture of the membranes, pregnancy-induced hypertension (pre-eclampsia).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5-10 IU once

Postpartum uterine haemorrhage

Population group: women, only adults (18 - 65 years old)

Postpartum hemorrhage co-occurrent and due to uterine rupture following obstructed labor

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 IU once

Caesarean section

Population group: women, only adults (18 - 65 years old)

During caesarean section, but following delivery of the child.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 IU once

Incomplete abortion, inevitable abortion, missed abortion

Population group: women, only adults (18 - 65 years old)

Early stages of pregnancy as an adjunctive therapy for the management of incomplete, inevitable, or missed abortion.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 IU once

Contraindications

Oxytocin is contraindicated in the following cases:

Hypertonic uterine contractions, mechanical obstruction to delivery, foetal distress

at least one of

Hypertonic uterine dysfunction
Obstructed labor
Fetal distress

Prostaglandins

at least one of

Prostaglandins
Prostaglandins
Prostaglandins

Conditions in which spontaneous labour is inadvisable and/or vaginal delivery is contra-indicated

at least one of

Cephalopelvic disproportion
Abnormal fetal presentation
Placenta previa
Vasa previa
Placental abruption
Presentation of cord
Prolapse of cord
Rupture of uterus
Polyhydramnios
† Grand multiparity - delivered
Scarring of uterus
Uterine scar from previous surgery affecting pregnancy

Patients with oxytocin-resistant uterine inertia, pre-eclamptic toxaemia, cardiovascular disorders

at least one of

Inefficient uterine activity with oxytocin augmentation
Pre-eclampsia
Cardiovascular disorder

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