Palovarotene

Chemical formula: C₂₇H₃₀N₂O₂ Molecular mass: 414.231 g/mol PubChem compound: 10295295

Therapeutic indications

Palovarotene is indicated for:

Fibrodysplasia ossificans progressiva

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Palovarotene is indicated for the reduction in volume of new heterotopic ossification in adults and pediatric patients aged 8 years and older for females and 10 years and older for males with fibrodysplasia ossificans progressiva (FOP).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

For patients 8-13 years old 2.5-5 mg once daily based on sex and body weight and for patients ≥14 years old 5 mg once daily

5 mg once daily

Contraindications

Palovarotene is contraindicated in the following cases:

Pregnancy

Lactation

History of allergy or hypersensitivity to retinoids

Retinoid allergy

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