Pemetrexed

Chemical formula: C₂₀H₂₁N₅O₆  Molecular mass: 427.411 g/mol  PubChem compound: 446556

Therapeutic indications

Pemetrexed is indicated for:

Malignant pleural mesothelioma

Population group: only adults (18 years old or older)

Pemetrexed in combination with cisplatin is indicated for the treatment of chemotherapy naïve patients with unresectable malignant pleural mesothelioma.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Non-small cell lung cancer

Population group: only adults (18 years old or older)

Pemetrexed in combination with cisplatin is indicated for the first line treatment of patients with locally advanced or metastatic non-small cell lung cancer other than predominantly squamous cell histology.

Pemetrexed is indicated as monotherapy for the maintenance treatment of locally advanced or metastatic non-small cell lung cancer other than predominantly squamous cell histology in patients whose disease has not progressed immediately following platinum-based chemotherapy.

Pemetrexed is indicated as monotherapy for the second line treatment of patients with locally advanced or metastatic non-small cell lung cancer other than predominantly squamous cell histology.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Pemetrexed is contraindicated in the following cases:

Lactation

Lactation

Yellow fever vaccine

Yellow fever vaccines

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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