Chemical formula: C₁₁H₁₂N₂O Molecular mass: 188.226 g/mol PubChem compound: 2206
Phenazone has analgesic and antipyretic properties. Topically, solutions containing 5% of phenazone have been used locally as ear drops in disorders such as otitis media because of its local anti-inflammatory and analgesic action. Glycerol softens wax.
Phenazone is readily absorbed from the gastro-intestinal tract and is distributed throughout the body fluids. Peak plasma concentrations are usually obtained in 1 to 2 hours. Less than 10% is bound to plasma proteins and it has a half-life of about 12 hours. Phenazone is metabolised in the liver, about 30% to 40% is metabolised to 4-hydroxyphenazone which is excreted in the urine as the glucuronide. Approximately 5% is excreted unchanged and approximately 6% is norphenazone in the urine.
Not applicable.
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