Chemical formula: C₁₈H₂₂ClNO Molecular mass: 303.826 g/mol PubChem compound: 4768
Phenoxybenzamine is a non competitive long acting α-adrenergic receptor antagonist.
Phenoxybenzamine is incompletely absorbed from the gastrointestinal tract. The maximum effect is attained in about 1 hour after an intravenous dose. Following oral administration the onset of action is gradual over several hours and persists for 3-4 days following a single dose. The plasma half-life is about 24 hours. Phenoxybenzamine is metabolised in the liver and excreted in the urine and bile but small amounts remain in the body for several days. It has prolonged action probably owing to stable covalent bonding.
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