Chemical formula: C₁₇H₁₉N₃O Molecular mass: 281.352 g/mol PubChem compound: 5775
Phentolamine is a competitive non-selective α1- and α2-adrenergic receptor blocker of relatively short duration of action. It causes vasodilatation and a fall in blood pressure resulting from the blockade of both post-junctional vascular α1- and α2-adrenoceptors. It also antagonises the vasoconstrictor response to noradrenaline and adrenaline infusions.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C04AB01 | Phentolamine | C Cardiovascular system → C04 Peripheral vasodilators → C04A Peripheral vasodilators → C04AB Imidazoline derivatives |
| V03AB36 | Phentolamine | V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ORAVERSE Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Phentolamine is an active ingredient of these brands:
United States (US)
Canada (CA)
Finland (FI)
France (FR)
Japan (JP)
Malta (MT)
South Africa (ZA)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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