Pimozide

Chemical formula: C₂₈H₂₉F₂N₃O  Molecular mass: 461.546 g/mol  PubChem compound: 16362

Therapeutic indications

Pimozide is indicated for:

Psychotic disorders

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Pimozide is an antipsychotic of the diphenylbutyl-piperidine series and is indicated in:

  • Chronic schizophrenia, for the treatment of symptoms and prevention of relapse.
  • Other psychoses, especially paranoid and monosymptomatic hypochondriacal psychoses (eg delusional parasitosis).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Pimozide is contraindicated in the following cases:

Lactation

Lactation

Effects on ability to drive and use machines

Effects on ability to drive and use machines

Severe central nervous system depression, depression, Parkinson's syndrome

at least one of
Central nervous system depression
Depressive disorder
Parkinson's disease
Coma

QT prolongation, drugs known to induce QT prolongation, history of cardiac arrhythmias, cardiac disorders

at least one of
Torsades de pointes
Acute myocardial infarction
Heart failure
Drugs inducing Torsade de Pointes
Risk factors that increase the risk of QT prolongation

CYP3A4 inhibitors, CYP2D6 inhibitors

at least one of
CYP3A4 inhibitors
CYP2D6 inhibitors

Serotonin uptake inhibitors

at least one of

Citalopram
Escitalopram

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Summary of Product Characteristics (SPC) 2016: ORAP Tablet
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