Pirfenidone

Chemical formula: C₁₂H₁₁NO  Molecular mass: 185.222 g/mol  PubChem compound: 40632

Therapeutic indications

Pirfenidone is indicated for:

Mild to moderate idiopathic pulmonary fibrosis (IPF)

Population group: only adults (18 years old or older)

Pirfenidone is indicated in adults for the treatment of mild to moderate idiopathic pulmonary fibrosis (IPF).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Pirfenidone is contraindicated in the following cases:

Severe renal impairment (CrCl <30 ml/min), dialysis

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)
Renal dialysis

Severe hepatic impairment or end stage liver disease

Hepatic failure stage IV

Fluvoxamine

Fluvoxamine

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