Plerixafor

Chemical formula: C₂₈H₅₄N₈  Molecular mass: 502.782 g/mol  PubChem compound: 65015

Therapeutic indications

Plerixafor is indicated for:

Autologous haematopoietic stem cells transplantation in lymphoma, multiple myeloma

Population group: only adults (18 years old or older)

Plerixafor is indicated in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in adult patients with lymphoma or multiple myeloma whose cells mobilise poorly.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Autologous haematopoietic stem cells transplantation in lymphoma, solid malignant tumours

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Plerixafor is indicated in combination with G-CSF to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children with lymphoma or solid malignant tumours, either:

  • pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilization with G-CSF (with or without chemotherapy) is expected to be insufficient with regards to desired hematopoietic stem cells yield, or
  • who previously failed to collect sufficient haematopoietic stem cells.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

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Summary of Product Characteristics (SPC) 2020: MOZOBIL Solution for injection
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