Chemical formula: C₂₂H₂₂O₈ Molecular mass: 414.405 g/mol PubChem compound: 10607
There are limited data from the use of podophyllotoxin in pregnant women.
Although there is very limited systemic absorption from topically applied podophyllotoxin, antimitotic products such as podophyllotoxin are known to be embryotoxic. Podophyllotoxin cream is not recommended during pregnancy or in women of childbearing potential not using contraception.
There is insufficient information on the excretion of topically applied podophyllotoxin in human milk.
A risk to the newborns/infants cannot be excluded.
A decision must be made whether to discontinue breastfeeding or to discontinue/abstain from podophyllotoxin therapy taking into account the benefit of breastfeeding for the child and the benefit of therapy for the woman.
None presently known.
The frequency of adverse reactions listed below is defined using the following convention: very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1,000, <1/100); rare (≥1/10,000, <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data). Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Very common: Skin erosion, application site irritation (including erythema, pruritus, skin burning sensation)
The following adverse drug reactions are based on post-marketing reports. Since these reports are from a population of uncertain size and are subject to confounding factors, it is not possible to reliably estimate their frequency, however in reality systemic reactions are rarely seen.
Not known: Application site hypersensitivity
Not known: Skin ulcer, scab, skin discoloration, blister, dry skin
Not known: Application site pain, swelling, application site bleeding
Not known: Caustic injury, excoriation, wound secretion
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