Ponesimod

Molecular mass: 460.97 g/mol  PubChem compound: 11363176

Therapeutic indications

Ponesimod is indicated for:

Relapsing forms of multiple sclerosis (RMS)

Population group: only adults (18 years old or older)

Ponesimod is indicated for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS) with active disease defined by clinical or imaging features.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Ponesimod is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Moderate hepatic impairment, severe hepatic impairment

at least one of
Hepatic failure stage III
Hepatic failure stage IV

Immunodeficient state

Immunodeficiency

Myocardial infarction, unstable angina, stroke, transient ischaemic attack (TIA), heart failure

at least one of
Myocardial infarction
Preinfarction syndrome
CVA - Cerebrovascular accident
Temporary cerebral vascular dysfunction
Decompensated cardiac failure
Heart failure
New York Heart Association Classification - Class III
New York Heart Association Classification - Class IV

Mobitz type II second-degree atrioventricular (AV) block, third-degree atrioventricular (AV) block, sick sinus syndrome

at least one of
Mobitz type II atrioventricular block
Complete atrioventricular block
Sick sinus syndrome

Severe active infections, active chronic infections

at least one of
Infectious disease
Chronic infectious disease

Active malignancies

Malignant tumour

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