Posaconazole

Chemical formula: C₃₇H₄₂F₂N₈O₄  Molecular mass: 700.777 g/mol  PubChem compound: 468595

Therapeutic indications

Posaconazole is indicated for:

Refractory invasive fungal infections (IFI)

Population group: only adults (18 years old or older)

Deep mycosis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Oropharyngeal candidiasis

Population group: only adults (18 years old or older)

at least one of
Candidiasis of mouth
Pharyngeal candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of invasive fungal infections

Population group: only adults (18 years old or older)

Preventive procedure and additionally Deep mycosis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Posaconazole is contraindicated in the following cases:

Ergot alkaloids

at least one of
Ergot alkaloids
Ergot alkaloids
Ergot alkaloids

Substrates known to prolong the QT-interval that are subject to metabolism by CYP3A4

Drugs prolonging QT interval and additionally CYP3A4 substrates

HMG-CoA reductase inhibitors metabolised through CYP3A4

HMG CoA reductase inhibitors and additionally CYP3A4 substrates

Terfenadine, astemizole, cisapride, pimozide, halofantrine, quinidine

at least one of
Terfenadine
Astemizole
Cisapride
Pimozide
Halofantrine
Quinidine

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