Potassium chloride

NSAIDs may produce potassium retention by reducing renal synthesis of prostaglandin E and impairing the renin-angiotensin system. Closely monitor potassium in patients on concomitant NSAIDs.

Increased risk of severe hyperkalaemia with the following:

• ACE-inhibitors.
• Aliskerin.
• Angiotensin-II receptor anatagonists.
• Potassium sparing diuretics such as: amiloride, spironolactone and triamterene and aldosterone antagonists.
• Ciclosporin.
• Tacrolimus (not topical formulations).

Potassium chloride should be used during pregnancy only under the supervision of the prescribing physician if considered essential by the physician.

Potassium chloride should be used during lactation only under the supervision of the prescribing physician if considered essential by the physician.

Carcinogenicity, mutagenicity and fertility studies in animals have not been performed. Potassium is a normal dietary constituent.

None known.