Prasterone

Molecular mass: 288.424 g/mol  PubChem compound: 5881

Therapeutic indications

Prasterone is indicated for:

Vulvar and vaginal atrophy in postmenopausal women having moderate to severe symptoms

Population group: women, only adults (18 years old or older)

at least one of
Senile atrophic vaginitis
Atrophic vulva

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Prasterone is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Fertility

Fertility

Porphyria

Porphyria

Undiagnosed genital bleeding

Observations of vaginal bleeding

Known breast cancer, past breast cancer, suspected breast cancer

at least one of
Malignant neoplasm of female breast
History of malignant neoplasm of breast

Known or suspected oestrogen-dependent malignant tumours (e.g endometrial cancer)

at least one of
Neoplasm of endometrium
Malignant neoplasm of female breast
Malignant tumour of ovary

Untreated endometrial hyperplasia

Endometrial hyperplasia

Acute liver disease, history of liver disease

at least one of
Hepatic failure stage IV
H/O: liver disease

Previous venous thromboembolism, current venous thromboembolism (deep vein thrombosis, pulmonary embolism)

at least one of
Thromboembolism of vein
Deep venous thrombosis
Pulmonary embolism

Known thrombophilic disorders (e.g. protein C, protein S, or antithrombin deficiency)

Thrombophilia

Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction)

Thromboembolic disorder

Jaundice, deterioration in liver function, increase in blood pressure, new onset of migraine-type headache

at least one of
Jaundice
Elevated blood pressure
Migraine variant with headache

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2022: INTRAROSA Pessary
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