Pravastatin and Fenofibrate

Therapeutic indications

Pravastatin and Fenofibrate is indicated for:

Mixed hyperlipidaemia in patients at high cardiovascular risk

Population group: only adults (18 years old or older)

Pravastatin/fenofibrate combination is indicated as an adjunct to diet and other non-pharmacological treatment (e.g. exercise, weight reduction) for the treatment of mixed hyperlipidaemia in adult patients at high cardiovascular risk to reduce triglycerides and increase HDL-C when LDL-C levels are adequately controlled while on a treatment with pravastatin 40 mg monotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Pravastatin and Fenofibrate is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Moderate renal impairment, severe renal impairment

at least one of



Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Moderate hepatic impairment, severe hepatic impairment

at least one of
Hepatic failure stage III
Hepatic failure stage IV

Known photo allergy or photo toxic reaction during treatment with fibrates or ketoprofen

Drug-induced photosensitivity and additionally at least one of
Fibrates
Ketoprofen

History of myopathy and/or rhabdomyolysis with statins and/or fibrates, creatine phosphokinase elevation after statin treatment

at least one of
Rhabdomyolysis due to statin
Increased creatine kinase level

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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