Pretomanid

Chemical formula: C₁₄H₁₂F₃N₃O₅ Molecular mass: 359.257 g/mol PubChem compound: 456199

Therapeutic indications

Pretomanid is indicated for:

Pulmonary tuberculosis due to Mycobacterium tuberculosis

Population group: only adults (18 years old or older)

Pretomanid is indicated in combination with bedaquiline and linezolid for the treatment of

adults with pulmonary tuberculosis (TB) due to Mycobacterium tuberculosis resistant to all of isoniazid, rifampicin, a fluoroquinolone and a second line injectable antibacterial drug and
adults with pulmonary TB due to M. tuberculosis resistant to both isoniazid and rifampicin, who are treatment-intolerant or nonresponsive to standard therapy.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

200 mg once daily for 26 weeks

Contraindications

Pretomanid is contraindicated in the following cases:

Lactation

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