Probenecid

Chemical formula: C₁₃H₁₉NO₄S  Molecular mass: 285.359 g/mol  PubChem compound: 4911

Interactions

Probenecid interacts in the following cases:

G6PD deficiency

Haemolytic anaemia has been observed which in some instances could be related to genetic deficiency of glucose-6-phosphate dehydrogenase in red blood cells.

Pregnancy

Category B2.

Probenecid crosses the placental barrier and appears in cord blood. The use of any medicine in women of childbearing potential requires that the anticipated benefit be weighed against possible hazards.

Reproduction studies in the rabbit and the rat at doses up to 10 times the recommended human dose have shown no evidence of teratogenic effects to the foetus due to probenecid. Because animal reproduction studies are not always predictive of human response, probenecid should be used during pregnancy only if clearly needed.

Nursing mothers

It is not known whether the medicine is excreted in human milk. Because many medicines are excreted in human milk, caution should be exercised when probenecid is administered to a nursing mother.

Effects on ability to drive and use machines

Although this medicine is unlikely to affect your ability to drive or operate machinery, a few people may be impaired and care should be taken.

Cross-check medications

Review your medication to ensure that there are no potentially harmful drug interactions or contraindications.

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