Ibenzmethyzine Other names: Procarbazine

Chemical formula: C₁₂H₁₉N₃O  Molecular mass: 221.299 g/mol  PubChem compound: 4915

Interactions

Ibenzmethyzine interacts in the following cases:

Interaction

at least one of
Barbiturates, plain
Barbiturates, plain
Antihistamines for systemic use
Phenothiazines with aliphatic side-chain
Phenothiazines with piperazine structure
Phenothiazines with piperidine structure

Pregnancy

Use of procarbazine is contraindicated during the first trimester of pregnancy, and should be avoided throughout the remainder of the gestational period.

Studies in animals have shown reproductive toxicity. The potential risk for humans is unknown. There are no adequate data from the use of Procarbazine in pregnant women, however isolated human foetal malformations have been reported following MOPP combination therapy.

Nursing mothers

Procarbazine is contraindicated during breast-feeding.

Carcinogenesis, mutagenesis and fertility

Fertility

Procarbazine has been reported to cause azoospermia and ovarian failure, which may be irreversible. It is extremely important that the patient is provided with appropriate information and advice, particularly as men may wish to have semen saved for use after Procarbazine treatment.

Effects on ability to drive and use machines

Patients should be warned of the possibility of lethargy.

Cross-check medications

Review your medication to ensure that there are no potentially harmful drug interactions or contraindications.

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