Propantheline

Animal reproduction and teratology studies have not been performed. Cohort data on parasympatholytics indicate a possible association with minor malformations. In view of this, propantheline should not be administered in pregnancy unless considered essential.

It is unknown whether propantheline bromide is excreted in human breast milk. No animal studies have been conducted. In view of this, propantheline should not be administered during breast-feeding unless considered essential. Suppression of lactation may occur with parasympatholytics.

Propantheline may produce drowsiness or blurred vision. Patients should not drive or operate machinery if affected in this way.

Side effects of antimuscarinics include dryness of the mouth with difficulty in swallowing and thirst, dilatation of the pupils with loss of accommodation and sensitivity to light, increased intra-ocular pressure, flushing, dryness of the skin, decreased sweating, heat stroke, bradycardia followed by tachycardia, palpitations and arrhythmias, urinary hesitancy and retention, constipation, reduced bronchial secretions, occasional confusion in the elderly, occasional nausea and vomiting, and occasional dizziness.